| Autor: |
H-B, Fiebrich, G, Van Den Berg, I P, Kema, T P, Links, J H, Kleibeuker, A P, Van Beek, A M E, Walenkamp, W J, Sluiter, E G E, De Vries |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Alimentary pharmacologytherapeutics. 32(11-12) |
| ISSN: |
1365-2036 |
| Popis: |
Somatostatin analogues are administered to control hormone hypersecretion in acromegaly and carcinoid patients. Somatostatin analogues can increase fat in the stools, which can lead to loss of fat-soluble vitamins. The effect of long-term somatostatin analogue use on vitamin levels remains unknown.To investigate the prevalence of fat-soluble vitamin deficiencies in long-term somatostatin analogue users.All acromegaly and carcinoid patients using somatostatin analogues for ≥ 18 months visiting the University Medical Center Groningen between December 2008 and April 2009 were eligible. Vitamin levels of fat-soluble vitamins in blood, clinical and vitamin-dependent laboratory parameters were collected.In all, 19 acromegaly and 35 carcinoid patients were included. Twelve patients experienced steatorrhoea; two carcinoid patients experienced night blindness. Forty-two (78%) were deficient for one or more vitamins, and 32% (n = 17) had multiple deficiencies. Deficiencies for vitamin A, D, E, K1 and E in erythrocytes occurred in 6%, 28%, 15%, 63% and 58% of the patients. Prevalence of vitamin D, E and K1 deficiencies was similar in both patient groups. Treatment duration did not influence vitamin levels. The length of intestinal resection and age correlated negatively with vitamin A levels.Fat-soluble vitamin deficiencies are frequent during long-term somatostatin analogue treatment. Therefore, fat-soluble vitamins should be monitored in these patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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