[Effects of Salvia miltiorrhiza on TGF-beta1, ROS and PAI-1 induced by angiotensin II in renal mesangial cells]
| Autor: | Jun, Yuan, Yan-fang, Lu, Tao-hou, Chen, Xiang-fa, Zeng |
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| Rok vydání: | 2008 |
| Předmět: |
Plants
Medicinal Dose-Response Relationship Drug Reverse Transcriptase Polymerase Chain Reaction Angiotensin II Blotting Western Gene Expression Salvia miltiorrhiza Injections Rats Transforming Growth Factor beta1 Mesangial Cells Plasminogen Activator Inhibitor 1 Animals RNA Messenger Reactive Oxygen Species Cells Cultured Drugs Chinese Herbal |
| Zdroj: | Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 32(22) |
| ISSN: | 1001-5302 |
| Popis: | To investigate the effect of Salvia miltiorrhiza on glomerulosclerosis induced by Ang II.Rat mesangial cells were exposed to 100 nmol L(-1) Ang II. Meanwhile, we added S. miltiorrhiza injection of different concentrations to Mcs. PAI-1 mRNA and protein, TGF-beta1 in serum free MEM medium, and the level of cellular reactive oxygen species (ROS) were measured.S. miltiorrhiza notably attenuated Ang II induced expression of PAI-1 in a concentration-dependent manner. Meanwhile, S. miltiorrhiza suppressed the production of TGF-beta1 and cellular ROS in mesangial cells.S. miltiorrhiza can alleviate glomerular sclerosis. The renoprotective effects of S. miltiorrhiza may be due to its ability to decrease Ang II -induced PAI-1 and TGF-beta1 secretion and cellular ROS level. |
| Databáze: | OpenAIRE |
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