Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells
Autor: | X F, Li, D S, Charnock-Jones, E, Zhang, S, Hiby, S, Malik, K, Day, D, Licence, J M, Bowen, L, Gardner, A, King, Y W, Loke, S K, Smith |
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Rok vydání: | 2001 |
Předmět: |
Umbilical Veins
Vascular Endothelial Growth Factor C Apoptosis Cytochrome c Group Endothelial Growth Factors Pregnancy Proteins Receptors TIE Angiopoietin-2 Proto-Oncogene Proteins Humans Receptors Growth Factor RNA Messenger Cells Cultured Menstrual Cycle Placenta Growth Factor Interleukin-15 Uterus Proteins Receptor Protein-Tyrosine Kinases Receptor TIE-1 Vascular Endothelial Growth Factor Receptor-3 Receptor TIE-2 Neoplasm Proteins Killer Cells Natural Receptors Vascular Endothelial Growth Factor Culture Media Conditioned Interleukin-2 Angiogenesis Inducing Agents Female Endothelium Vascular |
Zdroj: | The Journal of clinical endocrinology and metabolism. 86(4) |
ISSN: | 0021-972X |
Popis: | Angiogenesis is essential for endometrial growth and repair, and disruption of this process may lead to common disorders of women, including menorrhagia and endometriosis. In pregnancy, failure of the endometrial spiral arterioles to undergo remodeling leads to preeclampsia. Here we report that in addition to vascular endothelial growth factor A (VEGF-A), human endometrium expresses messenger ribonucleic acids (mRNAs) encoding VEGF-C, placenta growth factor (PlGF), the angiopoietins, angiopoietin 1 (Ang1) and Ang2, and the receptors VEGFR-3 (Flt-4), Tie 1, and Tie 2. Levels of VEGF-C, PlGF, and Tie 2 changed during the menstrual cycle. Intense hybridization for VEGF-C and PlGF mRNAs was found in uterine nature killer cells in secretory phase endometrium and for Ang2 mRNA in the same cells in the late secretory phase. Interleukin-2 (IL-2) and IL-15 up-regulated VEGF-C, but not PlGF or Ang2, mRNA levels in isolated NK cells. Conditioned medium from decidual NK cells did not induce human umbilical vein endothelial cell apoptosis. These results indicate that human endometrium expresses a wide range of angiogenic growth factors and that uterine nature killer cells may play an important role in the abnormal endometrial angiogenesis that underlies a range of disorders affecting women. |
Databáze: | OpenAIRE |
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