| Autor: |
W J, Pendergrast, W P, Drake, M R, Mardiney |
| Rok vydání: |
1975 |
| Předmět: |
|
| Zdroj: |
Journal of the National Cancer Institute. 55(5) |
| ISSN: |
0027-8874 |
| Popis: |
The therapeutic efficacy of polyadenlyic-polyuridylic acid (poly A-poly U) on the transplantable AKR leukemia varied with the dose of tumor cells implanted. The greater the number of AKR tumor cells injected into 8-week-old AKR mice free of clinical evidence of cancer, the greater the effect of poly A-poly U in mediating host immunologic control of the tumor. Poly A-poly U was either ineffective or could enhance tumor growth when smaller doses of tumor cells were transferred. The efficacy of an immune adjuvant depended on a tumor burden affording optimum host responsiveness. This does not necessarily arise in the host bearing minimal tumor burden. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
