| Autor: |
H, Oulhaj, S, Huynh, M, Langris, P, Barbey, J, Bocquet |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
Biochemistry and molecular biology international. 31(2) |
| ISSN: |
1039-9712 |
| Popis: |
In rat Sertoli cells, linoleate addition modified cell membrane fatty acid composition and changes depended on linoleate concentrations. In presence of the lowest 18:2 n-6 concentrations (2.5 and 7.5 microM), decrease in proteoglycan synthesis paralleled increase in n-6 linoleate-derived metabolites. At high concentration (21 microM), linoleate accumulated in membranes and level of n-6 linoleate-derived metabolites returned to basal value, without change in proteoglycan synthesis. Linoleate modified proteoglycan distribution in Sertoli cells by an increase in peripheral proteoglycans and a concomitant decrease in medium proteoglycans. Vitamin E (100 microM) did not alter fatty acid composition in control and linoleate-treated cells, but enhanced proteoglycan production. Furthermore, this agent counteracted linoleate-induced modifications in proteoglycan cell distribution. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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