In vitro and in vivo three-dimensional velocity vector measurement by three-beam spectral-domain Doppler optical coherence tomography

Autor: Wolfgang, Trasischker, René M, Werkmeister, Stefan, Zotter, Bernhard, Baumann, Teresa, Torzicky, Michael, Pircher, Christoph K, Hitzenberger
Rok vydání: 2013
Předmět:
Zdroj: Journal of biomedical optics. 18(11)
ISSN: 1560-2281
Popis: We developed a three-beam Doppler optical coherence tomography (OCT) system that enables measurement of the velocity vector of moving particles in three-dimensions (3-D). The spatial orientation as well as the magnitude of motion can be determined without prior knowledge of the geometry of motion. The system combines three spectral-domain OCT interferometers whose sample beams are focused at the sample by a common focusing lens at three different angles. This provides three spatially independent velocity components simultaneously from which the velocity vector can be reconstructed. We demonstrate the system in a simple test object (rotating disc), a flow phantom, and for blood flow measurements in the retina of a healthy human subject. Measurements of blood flow at a venous bifurcation achieve a good agreement between in- and outflow and demonstrate the reliability of the method.
Databáze: OpenAIRE