Early days of DNA repair: discovery of nucleotide excision repair and homology-dependent recombinational repair
| Autor: | W Dean, Rupp |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adenosine Triphosphatases
DNA Replication DNA Bacterial recombinational repair Endodeoxyribonucleases DNA Repair Ultraviolet Rays Escherichia coli Proteins Research education DNA Helicases History 20th Century nucleotide excision repair humanities recombination DNA-Binding Proteins leading strand restart Rec A Recombinases homology-dependent repair Pyrimidine Dimers Mutation Escherichia coli Focus: 50 Years of DNA Repair: The Yale Symposium Reports Homologous Recombination Yale Radiobiology |
| Zdroj: | The Yale Journal of Biology and Medicine |
| ISSN: | 1551-4056 |
| Popis: | The discovery of nucleotide excision repair in 1964 showed that DNA could be repaired by a mechanism that removed the damaged section of a strand and replaced it accurately by using the remaining intact strand as the template. This result showed that DNA could be actively metabolized in a process that had no precedent. In 1968, experiments describing postreplication repair, a process dependent on homologous recombination, were reported. The authors of these papers were either at Yale University or had prior Yale connections. Here we recount some of the events leading to these discoveries and consider the impact on further research at Yale and elsewhere. |
| Databáze: | OpenAIRE |
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