Possible tumor localization of Tc-99m-labeled liposomes: effects of lipid composition, charge, and liposome size

Autor: V J, Richardson, K, Jeyasingh, R F, Jewkes, B E, Ryman, M H, Tattersall
Rok vydání: 1978
Předmět:
Zdroj: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 19(9)
ISSN: 0161-5505
Popis: The possible in vivo distribution of liposomes after they have been directly labeled with Tc-99m has been studied in rats bearing the Walker 256 carcinoma. The importance of lipid composition, charge, and size of liposome were studied with respect to possible tumor-localizing properties. Tumor uptake was best with small, fluid-membrane, negatively charged liposomes, as indicated by the distribution of the Tc-99m label. The uptake was visualized on scintigrams.
Databáze: OpenAIRE