| Autor: |
Andrew, DeRouin, Roger, Guillory, Weilue, He, Megan, Frost, Jeremy, Goldman, Keat Ghee, Ong |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
Journal of biomedical materials research. Part B, Applied biomaterials. 107(2) |
| ISSN: |
1552-4981 |
| Popis: |
The gold standard of care for coronary artery disease, a leading cause of death for in the world, is balloon angioplasty in conjunction with stent deployment. However, implantation injuries and long-term presence of foreign material often promotes significant luminal tissue growth, leading to a narrowing of the artery and severely restricted blood flow. A promising method to mitigate this process is the use of biodegradable metallic stents, but thus far they have either degraded too slowly (iron) or disappeared prematurely (magnesium). The present work investigates the use of a unique type of magnetic material, galfenol (iron-gallium), for postoperative wireless control of stent degradation rates. Due to its magnetoelastic property, galfenol experiences longitudinal micron-level elongations when exposed to applied magnetic fields, allowing generation of a microstirring effect that affect its degradation behavior. In vitro indirect cytotoxicity tests on primary rat aortic smooth muscle cells indicated that galfenol byproducts must be concentrated approximately seven times from collected 60 day degradation medium to cause ∼15% of death from all cells. Surface and cross-sectional characterization of the material indicate that galfenol (Fe |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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