Anti-dopamine antibodies: effects on behavior in an 'open field,' pain sensitivity, CNS monoamine content, and functional activity of immunocytes in C57Bl/6 mice

Autor:	N A, Trekova, L A, Vetrilé, L A, Basharova, O I, Mikovskaya, T G, Khlopushina
Rok vydání:	2001
Předmět:	Central Nervous System Male B-Lymphocytes Behavior Animal Dopamine T-Lymphocytes Pain Motor Activity Mice Inbred C57BL Mice Phagocytosis Macrophages Peritoneal Animals Biogenic Monoamines Antibodies Blocking Pain Measurement
Zdroj:	Neuroscience and behavioral physiology. 31(1)
ISSN:	0097-0549
Popis:	Single i.p. doses of anti-dopamine antibodies were given to C57Bl/6 mice. This resulted in inhibition of motor activity in a large proportion of the animals in the "open field" test, which lasted five days. Hyperalgesia, detected 1.5 h and 1 day after doses of antibody, was replaced by analgesia on day 5. There was a sharp reduction in the levels of dopamine and its metabolites in the cerebral cortex at 1 and 5 days; the serotonin level was increased 1 day after doses of antibody, and was significantly decreased at 5 days. There was no effect on cells of the immune system. The possible mechanisms of the neurotropic action of these antibodies are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0f5fd69a0c4ca51b9b05496454bd7264 https://pubmed.ncbi.nlm.nih.gov/11265818 Zobrazit plný text záznamu Full text from SpringerLink