| Popis: |
The article exhibits the results of experimental studies in rats of vanadium and silver metabolism after isolated intratracheal introduction of the metals. Radioisotopic indication was used to investigate the processes of the metals' absorption in the blood, their distribution to the secondary depositories and elimination from the organism. A close correlation between specific stages of metabolism was identified, and the leading role of absorption in the toxicokinetics of the metals was established. It was proved that vanadium intensive absorption and transport were followed by its rapid elimination from the organs. Retention of silver at the introduction site--in the lungs was followed by its slower elimination. The data obtained is applicable in determining the site of toxicity effect. |
