| Autor: |
Jie, Yao, Shuming, Tang, Chenyan, Shi, Yunzhi, Lin, Lanlan, Ge, Qinghua, Chen, Baoru, Ou, Dongyu, Liu, Yuyang, Miao, Qiujie, Xie, Xudong, Tang, Jia, Fei, Guangyi, Yang, Jun, Tian, Xiaobin, Zeng |
| Rok vydání: |
2022 |
| Zdroj: |
Autophagy. |
| ISSN: |
1554-8635 |
| Popis: |
Isoginkgetin (ISO), a natural biflavonoid, exhibited cytotoxic activity against several types of cancer cells. However, its effects on hepatocellular carcinoma (HCC) cells and mechanism remain unclear. Here, we revealed that ISO effectively inhibited HCC cell proliferation and migration in vitro. LC3-II expression and autophagosomes were increased under ISO treatment. In addition, ISO-induced cell death was attenuated by treatment with chloroquine or knockdown of autophagy-related genes ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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