| Autor: |
Dong-mei, Wang, Shu-ying, Qi, Hai-bo, Yu, Chao, Ding, Hong-yun, Zang, Fu-li, Tian, Lei-sheng, Ru, Jie, Li, Bin, Zhang |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Zhonghua xin xue guan bing za zhi. 41(8) |
| ISSN: |
0253-3758 |
| Popis: |
To evaluate the incidence of super-response and the potential predictors related to super-response after cardiac resynchronization therapy (CRT) in patients with congestive heart failure.190 patients [145 men and 45 women;age: (60.48 ± 11.91) years] underwent CRT between March 2001 and March 2012 were enrolled in this multi-center trial, of which, 54 patients with ischemic cardiomyopathy and 136 patients with non-ischemic cardiomyopathy. These patients were followed up from 6 months to 11 years (mean 58 months) post CRT.Ten patients died within 6 months post CRT, the others were followed up for more than 6 months. At 6-month follow-up, 51 patients were identified as CRT super-responders (28.33%), 75 patients were CRT responders (41.67%) and 29 patients were CRT non-responders (16.11%), and 25 patients were CRT negative responders (13.89%). Super-response occurred more frequently in non-ischemic cardiomyopathy patients, while non-response most commonly occurred in ischemic cardiomyopathy patients (P0.05); patients in the negative response group had higher serum creatinine level than other groups (P0.05) , and patients in the non-response group and negative response group had higher pulmonary artery pressure than patients in the super-response group (P0.05); the average QRS duration was ≥ 160 ms before CRT, and the mean decrease was around 30 ms after CRT in the super-response group while the average QRS duration was 139 ms before CRT, and the mean reduction was around 8 ms after CRT in the negative response group (P0.05). LV lead position in the super-response group was usually in the middle and base of the heart, while in the negative response group it was more commonly located in the apex of the heart (P0.01) .LV lead located at the middle and pre-CRT ORS duration ≥ 160 ms are associated with super-response post CRT procedure in this patient cohort. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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