| Autor: |
Aleksandra, Szopa, Karolina, Bogatko, Anna, Serefko, Elżbieta, Wyska, Sylwia, Wośko, Katarzyna, Świąder, Urszula, Doboszewska, Aleksandra, Wlaź, Andrzej, Wróbel, Piotr, Wlaź, Jarosław, Dudka, Ewa, Poleszak |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Pharmacological reports : PR. 71(4) |
| ISSN: |
2299-5684 |
| Popis: |
Adenosine, an endogenous nucleoside, modulates the release of monoamines, e.g., noradrenaline, serotonin, and dopamine in the brain. Both nonselective and selective stimulation of adenosine receptors produce symptoms of depression in some animal models. Therefore, the main objective of our study was to assess the influence of a selective adenosine AThe forced swim test (FST) and tail suspension test (TST) were performed to assess the effects of DPCPX and DMPX on the antidepressant-like activity of agomelatine and tianeptine. Drug serum and brain levels were analyzed using HPLC.Co-administration of agomelatine (20 mg/kg) or tianeptine (15 mg/kg) with DMPX (3 mg/kg), but not with DPCPX (1 mg/kg), significantly reduced the immobility time both in the FST and TST in mice. These effects were not associated with an enhancement in animals' spontaneous locomotor activity. The observed changes in the mouse behavior after concomitant injection of DMPX and the tested antidepressant agents were associated with elevated brain concentration of agomelatine and tianeptine.Our study shows a synergistic action of the selective A |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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