| Autor: |
D, Bulgarini, D, Habetswallner, G, Boccoli, E, Montesoro, A, Camagna, G, Mastroberardino, C, Rosania, U, Testa, C, Peschle |
| Rok vydání: |
1989 |
| Předmět: |
|
| Zdroj: |
Annali dell'Istituto superiore di sanita. 25(3) |
| ISSN: |
0021-2571 |
| Popis: |
In the present study we have investigated the effect of Zn salts on the mitogenetic activation of human peripheral blood lymphocytes (PBL). Our results show that Zn2+ enhances the level of DNA synthesis in human T lymphocytes stimulated by a mitogenic lectin, phytohemagglutinin (PHA); this effect seems to be mediated through an enhanced expression of both interleukin-2 (IL-2) and transferrin (Trf) receptors. We have also analyzed the mitogenic effect of Zn2+ alone on PBL, in the absence of other mitogenic stimuli. In this regard we have identified large light density T lymphocytes as the PBL population which is activated to proliferate by Zn2+. Finally, we showed that Zn2+ stimulates natural killer (NK) activity; this effect is apparently not due to a direct action on NK lymphocytes, but is related to endogenous cytokines released by accessory cells which in turn stimulate the cytolytic activity of NK lymphocytes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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