| Autor: |
Spyridon, Fortis, Zacariah K, Shannon, Crystal J, Garcia, Rodrigo Vazquez, Guillamet, Ariel M, Aloe, Marin L, Schweizer, Victor, Kim, Rajeshwari, Nair |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Chest. 162(1) |
| ISSN: |
1931-3543 |
| Popis: |
The effect of nonobstructive chronic bronchitis (CB) on mortality is unclear.Is nonobstructive CB associated with increased all-cause mortality?We conducted a systematic literature review and meta-analysis to assess the association of nonobstructive CB and all-cause mortality. We searched for articles that included both CB and mortality in the title, abstract, or both in PubMed and EMBASE. We excluded studies in which participants demonstrated obstructive spirometry findings and studies in which CB and mortality were not defined. We used the Newcastle-Ottawa Quality Assessment Scale to assess study quality. We pooled adjusted hazard ratios (HRs) using the random effects model and inverse variance weighting. We conducted stratified analysis by the definition of CB and smoking status. We used Cochran's Q and IOf 5,014 titles identified, eight fulfilled the inclusion and exclusion criteria. Overall nonobstructive CB was associated with all-cause mortality (HR, 1.37; 95% CI, 1.26-1.50) with no statistically significant heterogeneity (P = .14; INonobstructive CB is associated with increased all-cause mortality, and this association seems to be present only in current and former smokers. Further research should investigate whether this high-risk population may benefit from early therapeutic intervention.PROSPERO; No.: CRD42021253596; URL: www.crd.york.ac.uk/prospero. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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