Sedative effects of medetomidine and its reversal by atipamezole in llamas
| Autor: | B M, Waldridge, H C, Lin, F J, DeGraves, D G, Pugh |
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| Rok vydání: | 1997 |
| Předmět: |
Time Factors
Dose-Response Relationship Drug Respiration Imidazoles Carbon Dioxide Hydrogen-Ion Concentration Medetomidine Injections Intramuscular Oxygen Heart Rate Injections Intravenous Animals Hypnotics and Sedatives Drug Interactions Prospective Studies Blood Gas Analysis Adrenergic alpha-Agonists Camelids New World Adrenergic alpha-Antagonists |
| Zdroj: | Journal of the American Veterinary Medical Association. 211(12) |
| ISSN: | 0003-1488 |
| Popis: | To determine a dose of medetomidine that will induce sedation in llamas, to assess effects of medetomidine sedation on arterial blood gas variables, and to determine efficacy of atipamezole in reversing medetomidine-induced sedation.Prospective, randomized clinical trial.15 clinically normal adult llamas.9 llamas received various doses of medetomidine (0.01, 0.02, or 0.03 mg/kg [0.005, 0.009, or 0.014 mg/lb] of body weight, i.m.). Heart and respiratory rates and sedative effects were recorded. Using the lowest dose that induced deep sedation, 6 different llamas were used to assess effects of medetomidine on arterial blood gas variables. These same 6 llamas were later given atipamezole (0.125 mg/kg [0.057 mg/lb], i.v.) 30 minutes after medetomidine injection. Heart and respiratory rates, sedative effects, and time from atipamezole injection to standing were recorded.Sedation began 6.67 +/- 1.15 minutes (mean +/- SD) after medetomidine administration (0.03 mg/kg, i.m.). Arterial blood gas variables measured 30 and 60 minutes after injection were not different from baseline. Llamas that did not receive atipamezole remained recumbent for 91.50 +/- 24.68 minutes. After atipamezole administration, llamas were able to stand in 5.80 +/- 3.27 minutes.Medetomidine induced light to deep sedation in a dose-dependent manner in clinically normal llamas. A dose of 0.03 mg/kg induced deep sedation with a short period of analgesia. Atipamezole rapidly reversed effects of medetomidine, and llamas recovered quickly and were soon able to stand. |
| Databáze: | OpenAIRE |
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