Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study

Autor:	Lisa, Stockdale, Basil, Sambou, Muhamed, Sissoko, Uzochukwu, Egere, Abdou K, Sillah, Beate, Kampmann, Robin, Basu Roy
Rok vydání:	2021
Předmět:	Adult Tuberculin Test Case-Control Studies Humans Tuberculosis Gambia Vitamin D Child
Zdroj:	European journal of pediatrics. 181(3)
ISSN:	1432-1076
Popis:	Using a matched case control design conducted at MRC Gambia in 2015, we measured vitamin D levels in pairs of asymptomatic children with discordant tuberculin skin test status despite the same sleeping proximity to the same adult TB index case. Median ages of groups (infected; 10.0 years, uninfected 8.8 years) were not significantly different (p = 0.13). Mean vitamin D levels were 2.05 ng/mL (95% CI - 0.288 to 4.38) higher in 24 highly TB-exposed uninfected children compared with 24 matched highly TB-exposed infected children (p = 0.08). The findings warrant further investigation in larger studies to understand the implications and significance. Conclusion: Vitamin D levels were higher in TB-uninfected children compared with TB-infected despite equal high exposure to a TB case.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0f1e96257fb0a3c65c119d2c61010a1a https://pubmed.ncbi.nlm.nih.gov/34643785 Zobrazit plný text záznamu Full text from SpringerLink