| Autor: |
J H, McClenathan, R A, Guyton, R H, Breyer, G E, Newman, L L, Michaelis |
| Rok vydání: |
1977 |
| Předmět: |
|
| Zdroj: |
The Journal of thoracic and cardiovascular surgery. 73(3) |
| ISSN: |
0022-5223 |
| Popis: |
The effects of isoproterenol and dopamine on regional myocardial blood flow were studied in 10 open-chest dogs after acute stenosis of the proximal circumflex coronary artery. Blood flow was determined by the radioactive microsphere technique. Isoproterenol led to a homogenous increase in blood flow in the normal myocardium. In the myocardium with compromised coronary blood flow, isoproterenol led to a relative subendocardial ischemia. This occurred despite increased aortic flow and peak left ventricular dp/dt. Dopamine also increased aortic flow and peak left ventricular dp/dt, but it did not cause regional myocardial ischemia. The findings suggest that dopamine is the preferable inotropic agent in managing low cardiac output in patients with significant coronary artery disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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