| Autor: |
Matthew C, Cheung, Anita R, Rachlis, Steven L, Shumak |
| Rok vydání: |
2003 |
| Předmět: |
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| Zdroj: |
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne. 168(4) |
| ISSN: |
0820-3946 |
| Popis: |
Cryptococcus neoformans commonly causes opportunistic infection in immunocompromised patients, especially in patients with AIDS. The CD4+ T-lymphocyte count is measured in patients with HIV infection, because it signals an increased risk of opportunistic infection and a decline in immunological function. We report a case of cryptococcal meningitis in a patient with persistently low CD4+ cell counts without evidence of HIV infection. The patient's underlying immunocompromised state was attributed to idiopathic CD4+ T-lymphocytopenia (ICL), a recently described syndrome characterized by depletions in the CD4+ T-cell subsets without evidence of HIV infection. Immunodeficiency can exist in the absence of laboratory evidence of HIV infection, highlighting the importance of evaluating T-cell subsets in patients who present with unusual infections. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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