Lack of evidence for small intestinal mucosal T-cell activation as a pathogenic mechanism in African HIV-associated enteropathy

Autor:	A M, Veitch, P, Kelly, I, Zulu, T T, MacDonald, M J, Farthing
Rok vydání:	2001
Předmět:	Adult Antigens Differentiation T-Lymphocyte Male Integrins Duodenum CD8 Antigens T-Lymphocytes Fluorescent Antibody Technique Zambia Receptors Interleukin-2 HLA-DR Antigens Middle Aged Lymphocyte Activation Antigens CD CD4 Antigens Intestine Small HIV Enteropathy Humans Female Intestinal Mucosa
Zdroj:	Digestive diseases and sciences. 46(5)
ISSN:	0163-2116
Popis:	The role of mucosal T-cell activation in HIV-associated enteropathy is uncertain. Twenty Zambian patients with AIDS and chronic diarrhea were studied, as were nine controls. Distal duodenal biopsies were taken at endoscopy. Morphometric analysis and dual color immunofluorescence staining were performed. Villous height was reduced [177 (118-228) vs 305 (244-358) microm P = 0.002] and crypt depth increased [220 (164-202) vs 194 (164-202) microm P = 0.008] in AIDS patients compared to controls. CD3+CD4+ T cells were reduced in AIDS patients compared to controls [12.9 (5.7-25.2) vs 47.6 (33.4-65.5)% P = 0.04]. There was no significant difference in expression of CD8, CD25, CD69, HML-1, or HLA-DR on T cells between the AIDS patients and controls, with the exception of CD3+HML-1+ cells, which were increased in AIDS patients (P = 0.05). Small intestinal T-cell activation was similar between AIDS patients and controls. We conclude, therefore, that this mechanism is not likely to be important in the pathogenesis of HIV-associated enteropathy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0ef390b2626f7d8df741030768c5f323 https://pubmed.ncbi.nlm.nih.gov/11341660 Zobrazit plný text záznamu Full text from SpringerLink