Light- and electron-microscopical study of a case of gold salt-induced hepatotoxicity

Autor:	G M, Fleischner, R, Morecki, T, Hanaichi, H, Hayashi, N, Quintana, I, Sternlieb
Rok vydání:	1991
Předmět:	Arthritis Rheumatoid Microscopy Electron Time Factors Liver Macrophages Humans Female Middle Aged Cytoplasmic Granules Lysosomes Gold Sodium Thiomalate Electron Probe Microanalysis
Zdroj:	Hepatology (Baltimore, Md.). 14(3)
ISSN:	0270-9139
Popis:	A 56-yr-old woman with long-standing rheumatoid arthritis exhibited jaundice, pruritus and abdominal discomfort after 8 yr of periodic gold sodium thiomalate injections amounting to a cumulative dose in excess of 2.5 gm. Histopathological examination of the liver biopsy specimen showed submassive loss of parenchyma, collapse of reticulin and mixed cellular inflammatory infiltrates. Macrophages contained dark granules, which displayed the characteristics of aurosomes when examined by transmission electron microscopy and electron microprobe analysis. It is likely that hepatocellular injury occurred when the lysosomal storage capacity for gold was exceeded.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0ef09556dd048cfdcd2ff485388a5339 https://pubmed.ncbi.nlm.nih.gov/1908434 Zobrazit plný text záznamu Plný text