Effects of bacterial lipopolysaccharide on the pharmacokinetics of DA-8159, a new erectogenic, in rats
| Autor: | Joo H, Lee, Yu C, Kim, Jong W, Kwon, Won B, Kim, Myung G, Lee |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Lipopolysaccharides
Male Sulfonamides Phosphodiesterase Inhibitors Vasodilator Agents Administration Oral Piperazines Sildenafil Citrate Rats Rats Sprague-Dawley Klebsiella pneumoniae Pyrimidines Erectile Dysfunction Purines Area Under Curve Injections Intravenous Animals Sulfones Infusions Intravenous Chromatography High Pressure Liquid Half-Life |
| Zdroj: | Research communications in molecular pathology and pharmacology. |
| ISSN: | 1078-0297 |
| Popis: | Pharmacokinetic parameters of DA-8159 and one of its metabolites, DA-8164, were compared after intravenous and oral administration of DA-8159 at a dose of 30 mg/kg to control rats and rats pretreated with Klebsiella pneumoniae lipopolysaccharide (KPLPS). After intravenous and oral administration of DA-8159, most of the pharmacokinetic parameters of DA-8159 and DA-8164 were not significantly different between two groups of rats. This suggested that the pharmacokinetic parameters of DA-8159 and DA-8164 were not affected considerably by KPLPS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|