| Autor: |
M J, Bannon, J M, Lee, P, Giraud, A, Young, H U, Affolter, T I, Bonner |
| Rok vydání: |
1986 |
| Předmět: |
|
| Zdroj: |
The Journal of biological chemistry. 261(15) |
| ISSN: |
0021-9258 |
| Popis: |
Rat genomic clones were used to quantitate preprotachykinin mRNAs in the rat basal ganglia, while the tachykinin peptide products substance P and substance K were measured by radioimmunoassay. Administration of the dopamine antagonist (antipsychotic) drug haloperidol significantly decreased substance P, substance K, and both alpha (substance P encoding) and beta (substance P/substance K encoding) preprotachykinin mRNAs, suggesting a drug-induced decrease in striatonigral tachykinin biosynthesis. The time course for decreased preprotachykinin mRNAs and tachykinins apparently parallels the period of maximum risk for the development of certain antipsychotic drug-induced extrapyramidal side effects seen clinically. Tachykinin interaction with dopamine neurons may play an important role in the modulation of basal ganglia function. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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