| Autor: |
R, Ramos Guerrero, J D, López Castilla, M, Atienza Fernández, J, Bautista Paloma, A J, Ramos Guerrero, M, Muñoz Sáez, M, Carranza Conde, J A, Soult Rubio |
| Rok vydání: |
2004 |
| Předmět: |
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| Zdroj: |
Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria. 27(6) |
| ISSN: |
1130-6343 |
| Popis: |
Patients with severe sepsis develop acquired protein C deficiency, and the extent of such deficiency and negative clinical outcomes correlate. Replacing this protein may help prevent such a condition. Two protein C types are commercially available - concentrated and activated proteins. None is registered for the treatment of severe sepsis in the pediatric setting. Experience with protein C in this group of conditions is limited. Appropriate clinical trials are required to establish effectiveness and safety, and to elucidate the role of either protein C type in the management of this condition in the pediatric setting. This paper discusses experience with the use of protein C concentrate as an adjuvant treatment in addition to conventional therapy in three children with severe sepsis at a Pediatric Intensive Care Unit. In all 3 cases of our study, high levels of protein C correlated to coagulation parameter normalization and reduced dimer D levels. Two out of three had a favorable outcome following treatment, whereas the third patient died as a result of septic shock and multiple organ dysfunction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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