[Damage to the structure of DNA and to the metabolism of nucleic acids in the thymus in relation to the dose of tritium oxide]

Autor: V B, Shorokhova, G G, Rusinova, G S, Mushkacheva
Rok vydání: 1990
Předmět:
Zdroj: Meditsinskaia radiologiia. 35(3)
ISSN: 0025-8334
Popis: Single administration of tritium oxide (1.1-44 MBq per 1 kg of body mass) causes a dose-dependent decrease in the level of rat thymus nucleic acids within the range of concentrations of injected tritium 5.5-44 MBq/g. Biosynthesis of nucleic acids turned out to be more sensitive to tritium oxide action. The rate of biosynthesis changed on the 1st day at the lowest dose of 1.1 MBq/g, the absorbed dose on the 1st day was 7.5 cGy. Dose-dependent disorders of DNA structure in the content of 2-strand DNA after the administration of tritium oxide (9-44 MBq/g) were established.
Databáze: OpenAIRE