| Autor: |
D L, Goode, D W, Newton, C T, Ueda, J E, Wilson, B G, Wulf, D, Kafonek |
| Rok vydání: |
1984 |
| Předmět: |
|
| Zdroj: |
Clinical pharmacy. 3(3) |
| ISSN: |
0278-2677 |
| Popis: |
The effect of an antacid on the bioavailability of lithium carbonate was determined in six healthy men in a crossover study. The volunteers were given single 300-mg doses of lithium carbonate alone and with 30 ml of an antacid containing aluminum and magnesium hydroxides with simethicone. Blood samples were collected at various times for 0-24 hours after each dose. The plasma samples were analyzed for lithium using a spectrophotometer, and bioavailability variables were calculated from plasma lithium concentration-time curves. There were no significant differences in peak plasma lithium concentration, time to peak concentration, area under the concentration-time curve from 0 to 24 hours, first-order absorption rate constant, and first-order elimination rate constant between the two treatments. Concurrent administration of antacids and lithium carbonate should not affect lithium blood concentrations. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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