High concentration of Daunorubicin and Daunorubicinol in human malignant astrocytomas after systemic administration of liposomal Daunorubicin

Autor:	K W, Albrecht, P C, de Witt Hamer, S, Leenstra, P J, Bakker, J H, Beijnen, D, Troost, P, Kaaijk, A D, Bosch
Rok vydání:	2001
Předmět:	Adult Male Antibiotics Antineoplastic Time Factors Daunorubicin Injections Intravenous Liposomes Osmolar Concentration Humans Female Astrocytoma Middle Aged Aged
Zdroj:	Journal of neuro-oncology. 53(3)
ISSN:	0167-594X
Popis:	The value of chemotherapy in patients with malignant astrocytoma remains controversial. In our laboratories in vitro experiments with organotypic spheroid cultures showed superior effectiveness of anthracyclines. Systemic administration did not provide in therapeutic concentrations so far. Because recent studies on Daunorubicin in liposomes in the treatment of Kaposi sarcoma have shown effectiveness with diminished systemic toxicity, we administered intravenously a single dose of Daunorubicin in liposomes in eight patients at different intervals prior to surgery (12-50 h). In samples taken from tumor, tumor-edge and where possible from adjacent brain, the levels of Daunorubicin and its active metabolite Daunorubicinol were assessed with high performance liquid chromatography. Here we report that high concentrations of Daunorubicin and Daunorubicinol were found in malignant gliomas after systemic administration of liposomal Daunorubicin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0ddc795bde559c2246e4bab70069593d https://pubmed.ncbi.nlm.nih.gov/11718259 Zobrazit plný text záznamu Full text from SpringerLink