Risk factors and outcomes associated with identification of Aspergillus in respiratory specimens from persons with HIV disease. Pulmonary Complications of HIV Infection Study Group
| Autor: | J M, Wallace, R, Lim, B L, Browdy, P C, Hopewell, J, Glassroth, M J, Rosen, L B, Reichman, P A, Kvale |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Lung Diseases Male Neutropenia AIDS-Related Opportunistic Infections Pneumonia Pneumocystis Smoking Sputum Marijuana Smoking Middle Aged CD4 Lymphocyte Count Cohort Studies Survival Rate Aspergillus Treatment Outcome Adrenal Cortex Hormones Risk Factors Case-Control Studies Cause of Death HIV Seropositivity Aspergillosis Humans Bronchoalveolar Lavage Fluid |
| Zdroj: | Chest. 114(1) |
| ISSN: | 0012-3692 |
| Popis: | To examine the significance of previously suggested risk factors and assess outcomes associated with Aspergillus identification in respiratory specimens from HIV-seropositive individuals.This was a nested case-control study. Patients who had Aspergillus species identified in respiratory specimens were matched at the time of study entry 1:2 with control subjects according to study center, age, gender, race, HIV transmission category, and CD4 count.The multicenter Pulmonary Complications of HIV Infection Study.HIV-seropositive study participants.Between November 1988 and March 1994, Aspergillus species were detected in respiratory specimens from 19 (1.6%) participants. The rate of Aspergillus identification among participants with CD4 counts200 cells per cubic millimeter during years 2 through 5 after study entry ranged from 1.2 to 1.9%. Neutropenia, a CD4 count30 cells per cubic millimeter, corticosteroid use, and Pneumocystis carinii infection were associated with subsequent identification of Aspergillus in respiratory specimens. Cigarette and marijuana use, previously suggested risk factors, were not associated with Aspergillus respiratory infection. A substantially greater proportion of patients with Aspergillus compared with control subjects died during the study (90% vs 21%). Excluding four cases first diagnosed at autopsy, 67% died within 60 days after Aspergillus was detected.Although Aspergillus is infrequently isolated from HIV-infected persons, the associated high mortality would support serious consideration of its clinical significance in those with advanced disease and risk factors. |
| Databáze: | OpenAIRE |
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