| Autor: |
Kazuha, Shosu, Masashi, Sakurai, Kumi, Inoue, Takayuki, Nakagawa, Hiroki, Sakai, Masahiro, Morimoto, Masaru, Okuda, Shunsuke, Noguchi, Takuya, Mizuno |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
In vivo (Athens, Greece). 30(3) |
| ISSN: |
1791-7549 |
| Popis: |
Antibody therapy targeting programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) is a promising therapy in human cancer, but only limited information on PD-L1 expression in canine tumors is available.PD-L1 expression was examined in 31 canine tumor cell lines of various origins by flow cytometry and western blotting, and in canine tumor and normal tissue specimens by immunohistochemistry.PD-L1 was only expressed on the cell surface of a small number of cell lines but was found expressed within the cells of almost all cell lines. Immunohistochemistry revealed that PD-L1 is frequently expressed in malignant melanoma, mammary gland tumor, mast cell tumor and lymphoma, but less frequently in soft-tissue sarcoma and hemangiosarcoma. PD-L1 was also expressed in some of the cells of normal canine tissue specimens.Canine tumors with PD-L1 expression that were identified in this study are potential candidates for antiPD-1 and antiPD-L1 therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
