| Autor: |
O, Nazareth, S, Devadatta, W, Fox, N K, Menon, S, Radhakrishna, D, Rajappa, C V, Ramakrishnan, P R, Somasundaram, H, Stott, S, Subbammal, S, Velu |
| Rok vydání: |
1971 |
| Předmět: |
|
| Zdroj: |
Bulletin of the World Health Organization. 45(5) |
| ISSN: |
0042-9686 |
| Popis: |
An earlier report showed that, in patients with bacteriologically quiescent pulmonary tuberculosis at the end of 1 year of chemotherapy, isoniazid alone in a single daily dose of 150-200 mg, given as maintenance therapy in the second year, did not markedly prevent relapse over a 4-year period of follow-up in patients who had had residual cavitation (the "open-negative" syndrome) at 1 year, but was highly effective in patients who had not. As a result of these findings, two controlled studies, reported here, were undertaken.The first study was undertaken in patients with bacteriologically quiescent disease and residual cavitation at 1 year, and investigated the value of isoniazid in a higher daily dose (400 mg) throughout the second year; this is known to be the optimum therapeutic dose when isoniazid is prescribed alone for 1 year in the initial treatment of the disease. The second study was carried out in patients with bacteriologically quiescent disease and no residual cavitation at 1 year, and sought to determine the value of a shorter duration (6 months) of chemotherapy in the second year with a daily dose of 300 mg of isoniazid. Neither of the two isoniazid regimens was highly satisfactory, although both appeared to have had some effect in preventing relapse during the 4-year period of follow-up. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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