| Autor: |
Josiah J, Newton, Gökçe, Engüdar, Alan J, Brooke, Matthew B, Nodwell, Holly, Horngren-Rhodes, Rainer E, Martin, Paul, Schaffer, Robert, Britton, Chadron M, Friesen |
| Rok vydání: |
2022 |
| Zdroj: |
Chemistry (Weinheim an der Bergstrasse, Germany). |
| ISSN: |
1521-3765 |
| Popis: |
The difluoromethyl group plays an important role in modern medicinal and agrochemistry. While several difluoromethylation reagents have been reported, these typically rely on difluoromethyl carbenes or anions, or target specific processes. Here, we describe a conceptually unique and general process for O-H, N-H and C-H difluoromethylation that involves the formation of a transient dithiole followed by facile desulfurative fluorination using silver(I) fluoride. We also introduce the 5,6-dimethoxy-1,3-benzodithiole (DMBDT) function, which undergoes sufficiently rapid desulfurative fluorination to additionally support |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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