[Anticonvulsive activity of antiepileptic drugs and quantum-chemical modelling of their interaction with GABA(A) receptor]

Autor:	L A, Gromov, O A, Evtushenko, V S, Kuts'
Rok vydání:	2005
Předmět:	Male Models Molecular Mice Binding Sites Models Chemical Seizures Excitatory Amino Acids Animals Quantum Theory Anticonvulsants Female Receptors GABA-A
Zdroj:	Ukrains'kyi biokhimichnyi zhurnal (1999 ). 76(6)
Popis:	The results of experimental analysis of the clinical activity of the antiepileptic drugs' (Phenobarbital, Carbamazepine, Valproic acid, Lamotrigine, Topiramate, Felbamate) widely used in clinic, that was carried out using the standard convulsion test with bicuculline in vivo were compared with characteristics of these drugs' interaction with the key aminoacids of GABA(A) receptor calculated by quantum chemical method (program HyperChem7, semi-empirical method AM1 technique). The correlation between the activity of the drugs in the experiment in vivo and energy of system's interaction of the drugs with aminoacid residue Thr201-Thr202-Gly203- Ala204-Tyr205-Pro206 was found out.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0d54a17bfa991df5938124afb0f52a62 https://pubmed.ncbi.nlm.nih.gov/16350754 Zobrazit plný text záznamu