| Autor: |
Hong-Wei, Cui, Zhong-Xia, Zhang, Ming-Tong, Gao, Yu, Liu, Ai-Hua, Su, Mei-Ying, Wang |
| Rok vydání: |
2008 |
| Předmět: |
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| Zdroj: |
Zhonghua xin xue guan bing za zhi. 36(1) |
| ISSN: |
0253-3758 |
| Popis: |
To observe the association between melatonin (MLT) secretion and blood pressure changes during 24 hours in hypertensive patients (HPT) with (dipping) or without (non-dipping) night time blood pressure reduction.The 24-hour blood pressure and urine 6-SMT (6-sulfatoxymelatonin, metabolism product of MLT in urine) in the daytime and nighttime were measured in normal control subjects (n = 20), non-dipping HPT group (n = 32) and dipping HPT group (n = 36).As expected, blood pressure reduction during the night was significantly lower in non-dipping HPT group compared to control and dipping HPT groups. Nighttime 6-SMT was significantly higher than daytime 6-SMT in all groups and nighttime urine 6-SMT levels and ratio of nighttime/daytime urine 6-SMT levels were significantly lower in non-dipping HPT group compared to control and dipping HPT groups (all P0.01). Moreover, ratio of nighttime/daytime urine 6-SMT levels are positively correlated blood pressure reduction during nighttime (P0.05) in all groups.Circadian rhythm of MLT secretion is maintained but nighttime MLT secretion was significantly reduced and related to disorders of circadian rhythm of blood pressure in non-dipping HPT group. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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