Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes

Autor: Lotta, Luca A., Pietzner, Maik, Stewart, Isobel D., Wittemans, Laura B.L., Li, Chen, Bonelli, Roberto, Raffler, Johannes, Biggs, Emma K., Oliver-Williams, Clare, Auyeung, Victoria P.W., Luan, Jian’an, Wheeler, Eleanor, Paige, Ellie, Surendran, Praveen, Michelotti, Gregory A., Scott, Robert A., Burgess, Stephen, Zuber, Verena, Sanderson, Eleanor, Koulman, Albert, Imamura, Fumiaki, Forouhi, Nita G., Khaw, Kay-Tee, Griffin, Julian L., Wood, Angela M., Kastenmüller, Gabi, Danesh, John, Butterworth, Adam S., Gribble, Fiona M., Reimann, Frank, Bahlo, Melanie, Fauman, Eric, Wareham, Nicholas J., Langenberg, Claudia
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nat Genet
ISSN: 1734-5286
Popis: Circulating levels of small molecules or metabolites are highly heritable, but the impact of genetic differences in metabolism on human health is not well understood. In this cross-platform, genome-wide meta-analysis of 174 metabolite levels across six cohorts including up to 86,507 participants (70% unpublished data), we identify 499 (362 novel) genome-wide significant associations (p
Databáze: OpenAIRE