Effects of subcutaneous administration of 3-methylcholanthrene and 7,12-dimethylbenz[a]anthracene on spontaneous reticulum cell neoplasms in SJL/J mice

Autor:	C E, Whitmire
Rok vydání:	1979
Předmět:	Mice 9 10-Dimethyl-1 2-benzanthracene Injections Subcutaneous Age Factors Benz(a)Anthracenes Animals Female Mice Inbred Strains Soft Tissue Neoplasms Lymphoma Large B-Cell Diffuse Sarcoma Experimental Methylcholanthrene
Zdroj:	Journal of the National Cancer Institute. 62(3)
ISSN:	0027-8874
Popis:	Inbred 4-week-old and 16-week-old SJL/J mice were treated sc with either 150 or 450 microgram 3-methylcholanthrene (MCA). No difference was noted in their subcutaneous tumor response related to age. Although the incidences of reticulum cell neoplasms (RCN's) were the same in the controls for the 2 age groups, more 16-week-old animals developed RCN's after carcinogen treatment than did 4-week-old SJL/J mice. More 16-week-old mice developed both subcutaneous tumors at the site of MCA injection and systemic RCN's than did mice treated at 4 weeks of age. This incidence was related to the coinciding of the chronologic age of the mice for RCN development with the latency for chemical carcinogen-induced subcutaneous tumor development. Mice treated with 7,12-dimethylbenz[a]anthracene at 16 weeks of age responded in the same way as did those treated with MCA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0d19d8eb54cb918bd88faa73f1627c2f https://pubmed.ncbi.nlm.nih.gov/105204 Zobrazit plný text záznamu