The role of a PDGF-activated nonselective cation channel in the proliferative response

Autor:	J J, Gargus, A M, Frace, F, Jung
Rok vydání:	1993
Předmět:	Platelet-Derived Growth Factor Sodium Tetraethylammonium Fibroblasts Tetraethylammonium Compounds Cosmids Resting Phase Cell Cycle Ion Channels Clone Cells Membrane Potentials Mice L Cells Cations Potassium Animals Cell Division Gene Library
Zdroj:	EXS. 66
ISSN:	1023-294X
Popis:	Murine fibroblasts have a 28 pS calcium- and voltage-insensitive NSC that becomes quiescent at G0 arrest and is rapidly and specifically activated by PDGF. Activation is produced by the discrete loss of long channel closures. The NSC can be rapidly and reversibly blocked with the NSAID flufenamic acid, through a prostaglandin-independent mechanism. The cell cycle (not viability) is blocked concomitantly with NSC block. A somatic cell mutant with altered NSC conductance has been isolated and used to clone the genomic locus of the channel. The mutant growth phenotype adds further support to the participation of NSC conductance in cell cycle control.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0d0f6802d6dfe7cc943ac5a8cfd6ca44 https://pubmed.ncbi.nlm.nih.gov/7505659 Zobrazit plný text záznamu