| Autor: |
Ahmed, Abdelbaki, Camilla, Ascanelli, Cynthia N, Okoye, H Begum, Akman, Giacomo, Janson, Mingwei, Min, Chiara, Marcozzi, Anja, Hagting, Rhys, Grant, Maria, De Luca, Italia Anna, Asteriti, Giulia, Guarguaglini, Alessandro, Paiardini, Catherine, Lindon |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Life science alliance. 6(2) |
| ISSN: |
2575-1077 |
| Popis: |
Mitotic kinase Aurora A (AURKA) diverges from other kinases in its multiple active conformations that may explain its interphase roles and the limited efficacy of drugs targeting the kinase pocket. Regulation of AURKA activity by the cell is critically dependent on destruction mediated by the anaphase-promoting complex (APC/C |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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