[Neurotransmitter balance in the CNS structure as effected by the combination of ionizing radiation and various doses of lead acetate]

Autor:	V N, Gurin, T V, Dudina, A I, Elkina, T S, Kandybo
Rok vydání:	1993
Předmět:	Central Nervous System Male Neurotransmitter Agents Dose-Response Relationship Drug X-Rays Radiation Dosage Rats Lead Radiation Ionizing Organometallic Compounds Animals Rats Wistar Corticosterone Protein Binding
Zdroj:	Radiatsionnaia biologiia, radioecologiia. 33(5)
ISSN:	0869-8031
Popis:	In experiments with mature Wistar male rats exposed to 25- and 50-fold fractionated doses of external X-ray radiation (0.5 Gy) and daily probe-assisted administration of plumbum acetate (100, 10, 5 mg/kg), similar, but differently marked changes in transmitter relationship in some CNS structures resembling the earlier found neurotransmitter disbalance during chronic stress of different ethiology were revealed. Combined exposure to plumbum and radiation led to more sustained and prolonged disorders to transmitter relationship associated with a sharp decrease in specific binding of corticosterone in CNS glucocorticoid-sensitive structures.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0ceca61a88a1a6172894e5e2bf8b871c https://pubmed.ncbi.nlm.nih.gov/7904880 Zobrazit plný text záznamu