| Autor: |
Tanya M, Laidlaw, Calman, Prussin, Reynold A, Panettieri, Stella, Lee, Berrylin J, Ferguson, Nithin D, Adappa, Andrew P, Lane, Marina L, Palumbo, Mary, Sullivan, Don, Archibald, Steven I, Dworetzky, Gregory T, Hebrank, Michael E, Bozik |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
The Laryngoscope. 129(2) |
| ISSN: |
1531-4995 |
| Popis: |
Chronic rhinosinusitis with nasal polyps (CRSwNP) and eosinophilia is a disease of the upper respiratory tract for which few therapies are available. Because the oral investigational drug dexpramipexole serendipitously decreased blood eosinophils in amyotrophic lateral sclerosis studies, we assessed its safety, eosinophil-lowering activity, and preliminary clinical efficacy in patients with CRSwNP and eosinophilia.Sixteen subjects with CRSwNP, absolute eosinophil count (AEC) ≥ 0.300 × 10Thirteen of 16 subjects completed 6 months of dexpramipexole treatment. Geometric mean baseline AEC was 0.525 ± 0.465 eosinophils × 10Dexpramipexole treatment produced profound eosinophil-lowering in peripheral blood and nasal polyp tissue. Despite the near-elimination of polyp eosinophils, decreased TPS and nasal symptom improvement were not observed.2 Laryngoscope, 129:E61-E66, 2019. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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