Systemic absorption of amitriptyline and buspirone after oral and transdermal administration to healthy cats

Autor:	K L, Mealey, K E, Peck, B S, Bennett, R K, Sellon, G R, Swinney, K, Melzer, S A, Gokhale, T M, Krone
Rok vydání:	2004
Předmět:	Cross-Over Studies Amitriptyline Skin Absorption Administration Oral Biological Availability Enzyme-Linked Immunosorbent Assay Antidepressive Agents Tricyclic Administration Cutaneous Buspirone Anti-Anxiety Agents Area Under Curve Eliminative Behavior Animal Cats Animals Female Prospective Studies
Zdroj:	Journal of veterinary internal medicine. 18(1)
ISSN:	0891-6640
Popis:	A prospective study was performed to determine the relative availability of buspirone and amitriptyline after oral and transdermal routes of administration in 6 adult cats. For topical administration, drugs were compounded in a transdermal organogel containing pluronic and lecithin (PLO). Using a crossover design, each cat received a single dose of amitriptyline (5 mg) and buspirone (2.5 mg) by the transdermal and oral route of administration with at least a 2-week washout interval between drug treatments. Blood samples were obtained at 0, 0.5, 1, 2, 4, 6, 8, 10, and 12 hours after drug administration for determination of plasma drug concentrations. Plasma concentrations of immunoreactive amitriptyline and buspirone were determined using commercial enzyme-linked immunosorbent assay (ELISA) tests. Systemic absorption of amitriptyline and buspirone administered by the transdermal route was poor compared with the oral route of administration. Until supporting pharmacokinetic data are available, veterinarians and cat owners should not rely on the transdermal route of administration for treating cats with amitriptyline or buspirone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0ccce8287b3973f1930aa7af3af1a087 https://pubmed.ncbi.nlm.nih.gov/14765730 Zobrazit plný text záznamu Plný text