Overexpression of the metastasis-associated gene MTA3 correlates with tumor progression and poor prognosis in hepatocellular carcinoma

Autor:	Chuanxi, Wang, Guanzhen, Li, Jiamei, Li, Jie, Li, Tao, Li, Jinyu, Yu, Chengyong, Qin
Rok vydání:	2016
Předmět:	Cell Nucleus Cytoplasm Carcinoma Hepatocellular Liver Neoplasms Gene Expression Prognosis Neoplasm Proteins Cell Movement Tumor Cells Cultured Humans Genetic Predisposition to Disease Neoplasm Invasiveness Neoplasm Metastasis Genetic Association Studies Cell Proliferation
Zdroj:	Journal of gastroenterology and hepatology. 32(8)
ISSN:	1440-1746
Popis:	Hepatocellular carcinoma (HCC) is one of the most common and aggressive cancers in the world. However, there remains a lack of effective diagnostic and treatment markers. We aimed to explore metastasis-associated protein 3 (MTA3) expression and function in HCC and its relationship with clinicopathological factors.We investigated the expression pattern and clinicopathological significance of MTA3 in 90 patients with HCC via immunohistochemistry and explored MTA3 function via gene knockdown of MTA3.MTA3 was overexpressed in HCC cell nuclei and downregulated in HCC cell cytoplasm. The former finding correlated with metastasis (P = 0.010) and poor prognosis (P = 0.018). In addition, deleting MTA3 inhibited HCC cell growth, invasion, and metastasis in vitro, as shown in the colony formation, migration, and wound-healing assays.These results indicate that MTA3 is an oncogene of HCC, predicts poor prognosis of HCC, and may be a future marker of HCC treatment.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0ca8d4bc739eef150b7808b2945695e9 https://pubmed.ncbi.nlm.nih.gov/27992674 Zobrazit plný text záznamu Plný text