Anaplasma marginale Yucatan (Mexico) Strain. Assessment of low virulence and potential use as a live vaccine

Autor: Sergio D, Rodríguez Camarillo, Miguel Angel, García Ortiz, Edmundo E, Rojas Ramírez, Germinal J, Cantó Alarcón, Jesús F, Preciado de la Torre, Rodrigo, Rosario Cruz, Juan A, Ramos Aragón, Ramón, Aboytes Torres
Rok vydání: 2009
Předmět:
Zdroj: Annals of the New York Academy of Sciences. 1149
ISSN: 1749-6632
Popis: Anaplasma marginale Yucatan strain was found to have low virulence in cattle. We studied the virulence of this isolate by experimental inoculation of 113 susceptible cattle at increasing doses, after which only one animal required treatment for clinical disease. Subsequently, 104 cattle received a live vaccine of this strain by inoculation, which induced immunoprotection after heterologous challenged exposure with a different A. marginale isolate. In this study 14% of the immunized cattle required treatment as compared with the control nonimmunized cattle, in which 56% required treatment. The A. marginale vaccine strains used for the immunization studies had MSP1a variable regions that were different from those used for the challenge exposure.
Databáze: OpenAIRE