Ventilation-perfusion heterogeneity measured by the multiple inert gas elimination technique is minimally affected by intermittent breathing of 100% O

Autor: Ann R, Elliott, Abhilash S, Kizhakke Puliyakote, Vincent, Tedjasaputra, Beni, Pazár, Harrieth, Wagner, Rui C, Sá, Jeremy E, Orr, G Kim, Prisk, Peter D, Wagner, Susan R, Hopkins
Rok vydání: 2019
Předmět:
Zdroj: Physiological Reports
ISSN: 2051-817X
Popis: Proton magnetic resonance (MR) imaging to quantify regional ventilation–perfusion ( V˙A/Q˙) ratios combines specific ventilation imaging (SVI) and separate proton density and perfusion measures into a composite map. Specific ventilation imaging exploits the paramagnetic properties of O2, which alters the local MR signal intensity, in an FIO2‐dependent manner. Specific ventilation imaging data are acquired during five wash‐in/wash‐out cycles of breathing 21% O2 alternating with 100% O2 over ~20 min. This technique assumes that alternating FIO2 does not affect V˙A/Q˙ heterogeneity, but this is unproven. We tested the hypothesis that alternating FIO2 exposure increases V˙A/Q˙ mismatch in nine patients with abnormal pulmonary gas exchange and increased V˙A/Q˙ mismatch using the multiple inert gas elimination technique (MIGET).The following data were acquired (a) breathing air (baseline), (b) breathing alternating air/100% O2 during an emulated‐SVI protocol (eSVI), and (c) 20 min after ambient air breathing (recovery). MIGET heterogeneity indices of shunt, deadspace, ventilation versus V˙A/Q˙ ratio, LogSD V˙, and perfusion versus V˙A/Q˙ ratio, LogSD Q˙ were calculated. LogSD V˙ was not different between eSVI and baseline (1.04 ± 0.39 baseline, 1.05 ± 0.38 eSVI, p = .84); but was reduced compared to baseline during recovery (0.97 ± 0.39, p = .04). There was no significant difference in LogSD Q˙ across conditions (0.81 ± 0.30 baseline, 0.79 ± 0.15 eSVI, 0.79 ± 0.20 recovery; p = .54); Deadspace was not significantly different (p = .54) but shunt showed a borderline increase during eSVI (1.0% ± 1.0 baseline, 2.6% ± 2.9 eSVI; p = .052) likely from altered hypoxic pulmonary vasoconstriction and/or absorption atelectasis. Intermittent breathing of 100% O2 does not substantially alter V˙A/Q˙ matching and if SVI measurements are made after perfusion measurements, any potential effects will be minimized.
Intermittent hyperoxia is used in proton magnetic resonance imaging to evaluate ventilation as part of measuring ventilation‐perfusion mismatch, but it may alter the underlying ventilation–perfusion distribution, especially when ventilation‐perfusion mismatch is increased. We used the multiple inert gas elimination technique to evaluate the effect of breathing alternating 2‐min‐100% oxygen with 2‐min‐21% oxygen on ventilation‐perfusion distributions in subjects with increased ventilation‐perfusion mismatch. There was a borderline increase in shunt, but no other significant effect on ventilation‐perfusion heterogeneity, suggesting that oxygen can be used to evaluate the ventilation‐perfusion distribution especially if perfusion images are acquired before oxygen is used in measuring ventilation.
Databáze: OpenAIRE
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