| Autor: |
Hitomi, Motomura, Yuka, Nozaki, Chotaro, Onaga, Ayaka, Ozaki, Shoma, Tamori, Taka-Aki, Shiina, Shotaro, Kanai, Chihiro, Ohira, Yasushi, Hara, Yohsuke, Harada, Ryoko, Takasawa, Takehisa, Hanawa, Sei-Ichi, Tanuma, Yasunari, Mano, Tsugumichi, Sato, Keiko, Sato, Kazunori, Akimoto |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Anticancer research. 40(1) |
| ISSN: |
1791-7530 |
| Popis: |
Co-expression of c-Met and ALDH1A3 indicates a poor prognosis in stage III-IV breast cancers and contributes to cell proliferation and tumor formation by ALDH1-positive breast CSCs. PKCλ is overexpressed and contributes to a poor prognosis in several cancers.A breast cancer genomics data set (METABRIC, n=2509) was downloaded and analyzed, as was the effect c-Met and PKCλ inhibitors on ALDH1c-Met expression correlates with expression of PKCλ in breast cancer. Stage III-IV breast cancer patients with c-Metc-Met and PKCλ are potentially useful prognostic markers and therapeutic targets in late-stage breast cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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