Mechanisms of regeneratory effects of baikal aconite diterpene alkaloids

Autor:	G N, Zyuz'kov, A V, Krapivin, Yu V, Nesterova, T N, Povetieva, V V, Zhdanov, N I, Suslov, T I, Fomina, E V, Udut, L A, Miroshnichenko, E V, Simanina, A A, Semenov, S S, Kravtsova, A M, Dygai
Rok vydání:	2012
Předmět:	Male Wound Healing Aconitum Aconitine Cell Differentiation Mesenchymal Stem Cells Mice Alkaloids Cellular Microenvironment Animals Outbred Strains Animals Intercellular Signaling Peptides and Proteins Regeneration Wounds and Injuries Diterpenes Stromal Cells Skin
Zdroj:	Bulletin of experimental biology and medicine. 153(6)
ISSN:	1573-8221
Popis:	Regeneratory activities of Baikal aconite alkaloids were studied on the excision skin wound model. Manifest wound healing effects of songorine, napelline, and hypaconitine were detected. The therapeutic efficiency was based on activation of residual mesenchymal progenitor elements. The development of this phenomenon was explained by the direct effects of alkaloids on precursors and by higher production of growth factors by the skin stromal cells. Songorine exhibited the most pronounced specific activity due to more significant stimulation of progenitor cell differentiation associated with maximum activation of the secretory function of the microenvironment cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::0c590b978055222bd9a41719796b5e1e https://pubmed.ncbi.nlm.nih.gov/23113300 Zobrazit plný text záznamu Full text from SpringerLink