| Autor: |
Paola, Viganò, Silvia, Mangioni, Maria Paola, Odorizzi, Annalisa, Chiodini, Sabrina, Rocca, Ilda, Chiodo |
| Rok vydání: |
2003 |
| Předmět: |
|
| Zdroj: |
Current opinion in investigational drugs (London, England : 2000). 4(10) |
| ISSN: |
1472-4472 |
| Popis: |
Endometriosis is an estrogen-dependent disorder mostly occurring in reproductive-age women. Various therapies have been used in an attempt to treat endometriosis, including ovarian suppression therapy, surgical treatment or a combination of these strategies. However, in general, substantial surgery remains the primary treatment option for endometriosis at all stages. Recently, aromatase inhibitors and anti-estrogens have been proposed as novel potential candidates. The rationale for the use of aromatase inhibitors is mostly related to the high aromatase expression in endometriotic cysts and extra-ovarian endometriotic implants. Among anti-estrogens, raloxifene has been investigated in animal models with good results, but in premenopausal women, the compound does not seem to suppress estrogen production. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
