| Autor: |
J D, Nieland, D M, Da Silva, M P, Velders, K E, de Visser, J T, Schiller, M, Müller, W M, Kast |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
Journal of cellular biochemistry. 73(2) |
| ISSN: |
0730-2312 |
| Popis: |
The use of chimeric virus-like particles represents a new strategy for delivering tumor antigens to the immune system for the initiation of antitumor immune responses. Immunization of DBA/2 mice with the P1A peptide derived from the P815 tumor-associated antigen P1A induced specific T-cell tolerance, resulting in progression of a regressor P815 cell line in all animals. However, immunization with a human papillomavirus type 16 L1 virus-like particle containing the P1A peptide in the absence of adjuvant induced a protective immune response in mice against a lethal tumor challenge with a progressor P815 tumor cell line. Additionally, we demonstrated that these chimeric virus-like particles could be used therapeutically to suppress the growth of established tumors, resulting in a significant survival advantage for chimeric virus-like particle-treated mice compared with untreated control mice. Chimeric virus-like particles can thus be used as a universal delivery vehicle for both tolerizing and antigenic peptides to induce a strong protective and therapeutic antigen-specific antitumor immune response. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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