| Autor: |
P, Muñoz-Cánoves, D P, Vik, B F, Tack |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
The Journal of biological chemistry. 265(33) |
| ISSN: |
0021-9258 |
| Popis: |
Retinoic acid receptors are members of the steroid/thyroid hormone receptor superfamily. Pursuant to the discovery that dexamethasone increases complement factor H expression, we examined the effects of retinoic acid on this gene. Both H mRNA and protein levels are increased by retinoic acid in L cells. Using the luciferase reporter gene system we have identified a region of the H promoter required for the retinoic acid response. This region contains an imperfect palindrome of the TGACC motif, present in thyroid hormone and estrogen-responsive elements. We demonstrate specific binding of the retinoic acid receptor beta to this sequence of the H gene by DNA-protein gel retardation assay. Therefore, these studies extend the sphere of influence of the retinoids to complement, an intrinsic component of the humoral immune system. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
