Liver histology and HBV DNA levels in chronically HBV infected patients with persistently normal alanine aminotransferase
| Autor: | Ghodrate, Montazeri, Maryam, Rahban, Mehdi, Mohamadnejad, Farhad, Zamani, Afshin, Hooshyar, Atoosa, Fazlolahi, Shifteh, Abedian, Farhad, Ghoujeghi, Arezoo, Estakhri, Farhad, Montazeri, Hadi, Razjoyan, Mansoureh, Mamarabadi, Meysam, Alimohamadi, Seyed Mohamad, Tavangar, Reza, Malekzadeh |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Hepatitis B virus Time Factors Risk Assessment Sensitivity and Specificity Severity of Illness Index Cohort Studies Hepatitis B Chronic Liver Function Tests Reference Values Humans Hepatitis B e Antigens Aged Monitoring Physiologic Retrospective Studies Analysis of Variance Biopsy Needle Age Factors Alanine Transaminase Middle Aged Immunohistochemistry ROC Curve DNA Viral Multivariate Analysis Linear Models Follow-Up Studies |
| Zdroj: | Archives of Iranian medicine. 13(3) |
| ISSN: | 1735-3947 |
| Popis: | Data on histological activity and HBV DNA levels in patients with chronic HBV infection and persistently normal alanine aminotransferase levels are sparse. We aimed to investigate the histological activity and HBV DNA levels in these patients.There were 132 patients with HBeAg negative chronic HBV infection and persistently normal alanine aminotransferase levels that were included prospectively. Data were dichotomized according to the median levels. Associations of histology with HBV DNA and other variables were assessed.A total of 80 patients were male. The median age was 36 years. The median baseline HBV DNA was 2.9Log10 IU/mL. There were 50 cases (38%) with a total scoreor = 5, 53 cases (40.2%) had gradeor = 4 and 40 cases (30.3%) had stageor = 2. A baseline HBV DNA2000 IU/mL was seen in 24 cases (48%) of those with total scoreor = 5, 28 cases (53%) of those with gradeor = 4 and 9 cases (22.5%) with stageor = 2. Multivariate analysis of baseline HBV DNA above the median level significantly predicted the total score, grade and stage with an adjusted odds ratio of 5.43, 3.47, and 4.23, respectively when compared to below median values. A second liver biopsy was performed in 61 patients. The median time interval between the two biopsies was 40 months. Total scores of 23 cases (38%) progressed byor = 2 scores and the HBV DNA of 18 cases (22.5%) increased byor = 1 Log10 IU when compared to baseline values.HBeAg negative chronic HBV infection with persistently normal alanine aminotransferase is not a silent disease. Active liver disease may be seen in such patients with viral loads less than 2000 IU/mL. |
| Databáze: | OpenAIRE |
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